其他名稱： PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)
分子量： 140kD
功能： Binds DNA and functions as a transcriptional regulator . Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling . ; [Isoform 4]: Binds DNA and functions as a transcriptional regulator . Functions as a repressor of TGF-beta signaling . May regulate granulocyte differentiation .
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Cytoplasm .
組織表達： Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.
科研貨號： PLA021562
PRD16 rabbit pAb
Catalog NoPLA021562
Product information
基因名稱： PRDM16 KIAA1675 MEL1 PFM13
蛋白名稱： PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)
其他名稱： PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)
分子量： 140kD
功能： Binds DNA and functions as a transcriptional regulator . Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling . ; [Isoform 4]: Binds DNA and functions as a transcriptional regulator . Functions as a repressor of TGF-beta signaling . May regulate granulocyte differentiation .
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Cytoplasm .
組織表達： Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.
科研貨號： PLA021562
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